Protein Interaction Antibody Pairs
BIORTUS USA INC Gene Name: CDK4/CCND3. Uniprot: P11802/P30281. Construct:GST-3C-CDK4(1-303end)/His-3C-Cyclin D3(1-292). Purity: 80%. 1 each contains 100UG.
Ser/Thr-kinase component of Cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Component of the ternary complex, Cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the Cyclin D-CDK4 complex. Shows transcriptional coactivator activity with ATF5 independently of CDK4.
Cayman Chemical mP-9 Q279R VarInthumnr 20ug
Active recombinant C-terminal His-tagged protein expressed in HEK293 cells • Amino acids: 20-707 • MW: 77.8 kDa
ABclonal Technology Phospho-eIF4EBP1-T70
This gene encodes one member of a family of translation repressor proteins The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E) which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5 end of mRNAs Interaction of this protein with eIF4E inhibits complex assembly and represses translation This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling resulting in its dissociation from eIF4E and activation of mRNA translation
ABclonal Technology WEE1 Rabbit mAb
This gene encodes a nuclear protein which is a tyrosine kinase belonging to the Ser Thr family of protein kinases This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2 cyclin B kinase and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase
HORIZON DISCOVERY BIOSCIENCES LIMITED SMARTVECTOR MSE ERN1 MEF1A-TUR
NC3839037 SMARTVECTOR MSE ERN1 MEF1A-TUR
Sino Biological Recombinant Human AMPK Protein (full length, His Tag)
Recombinant full-length human AMPK (combination of A2/B2/G3 subunits) was expressed by baculovirus in Sf9 insect cells using C-terminal His tags.
ABclonal Technology Phospho-MDM2-S166 Rabbit mAb
This gene encodes a nuclear-localized E3 ubiquitin ligase The encoded protein can promote tumor formation by targeting tumor suppressor proteins such as p53 for proteasomal degradation This gene is itself transcriptionally-regulated by p53 Overexpression or amplification of this locus is detected in a variety of different cancers There is a pseudogene for this gene on chromosome 2 Alternative splicing results in a multitude of transcript variants many of which may be expressed only in tumor cells
ABclonal Technology p-PLC gamma 1 PLCG1-Y783
The protein encoded by this gene catalyzes the formation of inositol 1 4 5-trisphosphate and diacylglycerol from phosphatidylinositol 4 5-bisphosphate This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators For example when activated by SRC the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi where it activates Ras Also this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase Two transcript variants encoding different isoforms have been found for this gene
ABclonal Technology Phospho-MDM2-S166 Rabbit mAb
This gene encodes a nuclear-localized E3 ubiquitin ligase The encoded protein can promote tumor formation by targeting tumor suppressor proteins such as p53 for proteasomal degradation This gene is itself transcriptionally-regulated by p53 Overexpression or amplification of this locus is detected in a variety of different cancers There is a pseudogene for this gene on chromosome 2 Alternative splicing results in a multitude of transcript variants many of which may be expressed only in tumor cells